(5-Amino-1H-[1,2,4]triazol-3-yl)-methanol synthesis

Yield:27277-03-8 52%

Reaction Conditions:

with nitric acid in water at 5; for 40.5 h;Heating / reflux;

Steps:

B.75.1 Step 1: (5-AMINO-1H- [1, 2, 4] TRIAZOL-3-YI)-METHANOL

A solution of glycolic acid (70 % in water, 70 mL, 805 mmol) was added to aminoguanidine bicarbonate (55.12 G, 405 mmol) carefully. After foaming subsided, concentrated nitric acid (0.5 mL) was added and the entire reaction was refluxed for 40 hours. The reaction was cooled to 5 C for 30 minutes, and the solids were filtered. The solids were then triturated with EtOH for 1 hour. The product was then filtered and dried under nitrogen (40.36 g, 52% yield). MS (ESI) : 115 (M+H).

References:

WO2004/74270,2004,A2 Location in patent:Page 327