ChemicalBook CAS DataBase List 5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester

5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester synthesis

4synthesis methods

Product Name:5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester
CAS Number:474330-54-6
Molecular formula:C9H10BrNO2
Molecular Weight:244.09

18595-18-1 Synthesis

18595-18-1
342 suppliers
$8.00/10g

5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester

474330-54-6
73 suppliers
$62.77/0.5g

Yield: 90%

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide at 0; for 0.333333 h;

Steps:

4.1 Step 1: Preparation of methyl 5-amino-2-bromo-4-methylbenzoate (4-b)
Dissolve methyl 3-amino-4-methylbenzoate (5g, 30.27mmol) in DMF (50mL), cool the system to 0 ° C, add NBS (5.39g, 30.27mmol) in portions, and stir at this temperature 20 minutes, TLC detection, the reaction was completed, the reaction solution was dropped into water, extracted with ethyl acetate, washed with water, dried, concentrated, and the residue was purified by silica gel column chromatography (eluent: petroleum ether / ethyl acetate = 2 / 1) The title compound (6.65 g, yield: 90.0%) was obtained in this step.

References:

Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.;Liu Jinming;Cai Jiaqiang;Tang Jianchuan;Wang Kunjian;Wang Lichun;Wang Jingyi CN110655503, 2020, A Location in patent:Paragraph 0254; 0255; 0256-0257

67-56-1 Synthesis