![](/CAS/GIF/13382-43-9.gif)
5-AMINO-2-METHYLBENZOTHIAZOLE synthesis
- Product Name:5-AMINO-2-METHYLBENZOTHIAZOLE
- CAS Number:13382-43-9
- Molecular formula:C8H8N2S
- Molecular Weight:164.23
![2-METHYL-5-NITROBENZOTHIAZOLE](/CAS/GIF/2941-66-4.gif)
2941-66-4
45 suppliers
$101.00/1g
![5-AMINO-2-METHYLBENZOTHIAZOLE](/CAS/GIF/13382-43-9.gif)
13382-43-9
104 suppliers
$30.00/1g
Yield:13382-43-9 98%
Reaction Conditions:
with ammonium chloride;iron in methanol;water for 2 h;Reflux;
Steps:
1
To a mixture of 3.08 g (15.9 mmol) of 2-methyl-5-nitrobenzo[d]thiazole, 4.87 g (87.2 mmol) of powdered iron, and 6.79 g (126 mmol) of ammonium chloride was added 120 mL of methanol, and 30 mL of water. The mixture was stirred and heated at reflux for 2 h, then cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo, then the residue was partitioned between 60 mL of ethyl acetate and 40 mL of 10% Na2CO3. The combined ethyl acetate layers were dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified via silica gel chromatography, eluting with 2:1 petroleum ether: ethyl acetate to give 2.55 g (98%) of a pale yellow solid.
References:
SIRTRIS PHARMACEUTICALS, INC. WO2009/85226, 2009, A2 Location in patent:Page/Page column 117
![5-Chloro-2-methylbenzothiazole](/CAS/GIF/1006-99-1.gif)
1006-99-1
192 suppliers
$12.69/1g
![5-AMINO-2-METHYLBENZOTHIAZOLE](/CAS/GIF/13382-43-9.gif)
13382-43-9
104 suppliers
$30.00/1g
![N-(2-BROMO-5-NITROPHENYL)ACETAMIDE](/CAS/GIF/90221-50-4.gif)
90221-50-4
12 suppliers
$150.00/1 G
![5-AMINO-2-METHYLBENZOTHIAZOLE](/CAS/GIF/13382-43-9.gif)
13382-43-9
104 suppliers
$30.00/1g
![2-Bromo-5-nitroaniline](/CAS/GIF/10403-47-1.gif)
10403-47-1
199 suppliers
$22.00/5g
![5-AMINO-2-METHYLBENZOTHIAZOLE](/CAS/GIF/13382-43-9.gif)
13382-43-9
104 suppliers
$30.00/1g
![Acetamide, N-(2-methyl-5-benzothiazolyl)- (9CI)](/CAS/GIF/68867-15-2.gif)
68867-15-2
6 suppliers
inquiry
![5-AMINO-2-METHYLBENZOTHIAZOLE](/CAS/GIF/13382-43-9.gif)
13382-43-9
104 suppliers
$30.00/1g