5-AMINO-3-CHLOROPYRAZINE-2-CARBONITRILE synthesis
- Product Name:5-AMINO-3-CHLOROPYRAZINE-2-CARBONITRILE
- CAS Number:34617-65-7
- Molecular formula:C5H3ClN4
- Molecular Weight:154.56
Yield:34617-65-7 90%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in 1-methyl-pyrrolidin-2-one at 100; for 14 h;
Steps:
32.b Step B. 5-Amino-3-chloropyrazine-2-carbonitrile.
A mixture of 6-chloro-5-iodopyrazin-2-amine (17.2 g, 67.7 mmol), Zn(CN)2 (4.35 g, 37.2 mmol) and Pd(PPh3)4 (3.9 g, 3.4 mmol) in NMP was heated at 100°C for 14 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography using Petroleum Ether:EtOAc 1 :4 as eluting solvents to afford 5-amino-3-chloropyrazine- 2-carbonitrile as a yellow solid (9.4 g, 90%). MS (ESI) m/z: 155 [M+H]+.
References:
WO2015/100609,2015,A1 Location in patent:Page/Page column 53
34617-64-6
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