![](/CAS/20180906/GIF/39906-04-2.gif)
5-Amino-4,6-dichloro-2-methylpyrimidine synthesis
- Product Name:5-Amino-4,6-dichloro-2-methylpyrimidine
- CAS Number:39906-04-2
- Molecular formula:C5H5Cl2N3
- Molecular Weight:178.02
![4,6-Dichloro-2-methyl-5-nitropyrimidine](/CAS/GIF/13162-43-1.gif)
13162-43-1
121 suppliers
$7.00/250mg
![5-Amino-4,6-dichloro-2-methylpyrimidine](/CAS/20180906/GIF/39906-04-2.gif)
39906-04-2
235 suppliers
$10.00/1g
Yield:39906-04-2 84%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethyl acetate at 20; for 4 h;
Steps:
1 5.4 General procedure for preparation of 4,6-dichloro-2-substituted-5- nitropyrimidine (11a,b)
General procedure: 10% Pd/C(0.05) gwas added to the solution of substituted pyrimidine (4.48mmol) in ethyl acetate (EA, 20mL) in Parr hydrogenater. Then, replace the air with nitrogen three times, and react for 4hat room temperature in normal pressure. Filter the solution to remove Pd/C through Celite filter agent, the filtrate was concentrated to yield the intermediates 11a,b [46]. 5.4.1 4,6-Dichloro-2-methyl-5-nitropyrimidine (11a) Pale solid; Yield: 84.0%; MS (ESI) m/z: 177.94 [M+H]+.
References:
Huang, Daowei;Huang, Lei;Zhang, Qingwei;Li, Jianqi [European Journal of Medicinal Chemistry,2017,vol. 140,p. 212 - 228]
![5-AMINO-4,6-DIHYDROXY-2-METHYLPYRIMIDINE](/CAS/GIF/98797-08-1.gif)
98797-08-1
19 suppliers
$45.00/10mg
![5-Amino-4,6-dichloro-2-methylpyrimidine](/CAS/20180906/GIF/39906-04-2.gif)
39906-04-2
235 suppliers
$10.00/1g
![4,6-Dichloro-2-methyl-5-nitropyrimidine](/CAS/GIF/13162-43-1.gif)
13162-43-1
121 suppliers
$7.00/250mg
![Iron](/CAS/GIF/7439-89-6.gif)
7439-89-6
422 suppliers
$10.00/25g
![5-Amino-4,6-dichloro-2-methylpyrimidine](/CAS/20180906/GIF/39906-04-2.gif)
39906-04-2
235 suppliers
$10.00/1g
![4,6-Dihydroxy-2-methylpyrimidine](/CAS/GIF/1194-22-5.gif)
1194-22-5
125 suppliers
$6.00/5g
![5-Amino-4,6-dichloro-2-methylpyrimidine](/CAS/20180906/GIF/39906-04-2.gif)
39906-04-2
235 suppliers
$10.00/1g
![2-METHYL-5-NITRO-PYRIMIDINE-4,6-DIOL](/CAS/GIF/53925-27-2.gif)
53925-27-2
50 suppliers
inquiry
![5-Amino-4,6-dichloro-2-methylpyrimidine](/CAS/20180906/GIF/39906-04-2.gif)
39906-04-2
235 suppliers
$10.00/1g