5-Amino-N-cyclopropylpyridine-2-carboxamide synthesis
- Product Name:5-Amino-N-cyclopropylpyridine-2-carboxamide
- CAS Number:1206592-83-7
- Molecular formula:C9H11N3O
- Molecular Weight:177.2
24242-20-4
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Yield:-
Reaction Conditions:
with triethylamine;HATU in N,N-dimethyl-formamide at 20; for 16 h;
Steps:
5-Amino-pyridine-2-carboxylic acid (leq.), HATU (1.5 eq.) and Et3N (2eq.) are mixed in DMF at room temperature. Cyclopropylamine (l.leq.) is added to the solution and the reaction mixture is stirred at room temperature for 16hrs. Water is added to the reaction. The organic phases are isolated, dried over MgSO/i, filtered and evaporated under vacuum to afford the expected product. In same cases, purification by flash chromatography is required.
References:
WO2010/10189,2010,A1 Location in patent:Page/Page column 59