![](/CAS/GIF/14597-58-1.gif)
5-Amino-thiophene-2-carboxylic acid methyl ester synthesis
- Product Name:5-Amino-thiophene-2-carboxylic acid methyl ester
- CAS Number:14597-58-1
- Molecular formula:C6H7NO2S
- Molecular Weight:157.19
![5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER](/CAS/GIF/5832-01-9.gif)
5832-01-9
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$6.00/1g
![5-Amino-thiophene-2-carboxylic acid methyl ester](/CAS/GIF/14597-58-1.gif)
14597-58-1
101 suppliers
$26.00/100mg
Yield: 100%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethyl acetate at 20; for 2 h;
Steps:
Step 1: Methyl 5-aminothiophene-2-carboxylate
Into a 30-mL round-bottom flask purged and maintained with 1 atmosphere of hydrogen gas, was placed methyl 5-nitrothiophene-2-carboxylate (500 mg, 2.67 mmol), 10% Pd/C (500 mg, 0.47 mmol) in EA (10 mL). The resulting solution was stirred 2.0 h at room temperature. The reaction progress was monitored by LCMS. The mixture was filtered through a CELITE pad. The resulting mixture was concentrated under vacuum to yield methyl 5-aminothiophene-2-carboxylate as a white solid (420 mg, 100% yield). Mass spectrum (ESI, m/z): Calculated for C6H7NO2S, 157.0, Measured: 158.3 [M+H]+.
References:
Zhang, Xuqing;Zhu, Bin;Sun, Weimei;Wang, Mina;Albarazanji, Kamal;Ghosh, Brahma;Cummings, Maxwell;Lenhard, James;Leonard, James;Macielag, Mark;Lanter, James [Bioorganic and Medicinal Chemistry Letters,2021,vol. 40,art. no. 127939] Location in patent:supporting information
![2-Thiophenecarboxylic acid](/CAS/GIF/527-72-0.gif)
527-72-0
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![5-Amino-thiophene-2-carboxylic acid methyl ester](/CAS/GIF/14597-58-1.gif)
14597-58-1
101 suppliers
$26.00/100mg
![4-AMINO-THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/89499-43-4.gif)
89499-43-4
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$27.00/250mg
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
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![2-Thiophenecarboxylic acid](/CAS/GIF/527-72-0.gif)
527-72-0
483 suppliers
$5.00/10g
![5-Amino-thiophene-2-carboxylic acid methyl ester](/CAS/GIF/14597-58-1.gif)
14597-58-1
101 suppliers
$26.00/100mg
![4-AMINO-THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/89499-43-4.gif)
89499-43-4
93 suppliers
$27.00/250mg
![5-NITROTHIOPHENE-2-CARBOXYLICMETHYLESTER](/CAS/GIF/5832-01-9.gif)
5832-01-9
77 suppliers
$6.00/1g
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7439-89-6
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14597-58-1
101 suppliers
$26.00/100mg
![5-Nitrothiophene-2-carboxylic acid](/CAS/GIF/6317-37-9.gif)
6317-37-9
190 suppliers
$5.00/1g
![5-Amino-thiophene-2-carboxylic acid methyl ester](/CAS/GIF/14597-58-1.gif)
14597-58-1
101 suppliers
$26.00/100mg