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5-benzyl-1,2,4-oxadiazole-3-carboxylic Acid synthesis
- Product Name:5-benzyl-1,2,4-oxadiazole-3-carboxylic Acid
- CAS Number:19706-09-3
- Molecular formula:C10H8N2O3
- Molecular Weight:204.18
![Ethyl 5-Benzyl-1,2,4-oxadiazole-3-carboxylate](/CAS/20140525/GIF/CB31873888.gif)
1216803-85-8
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$130.78/1gm:
![5-benzyl-1,2,4-oxadiazole-3-carboxylic Acid](/CAS/20200611/GIF/19706-09-3.gif)
19706-09-3
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Yield:19706-09-3 82%
Reaction Conditions:
with lithium hydroxyde monohydrate;lithium hydroxide monohydrate in tetrahydrofuran at 20; for 4 h;
Steps:
13 Synthesis of Compound 5-benzyl-1,2,4-oxadiazole-3-carboxylic acid(ZSQ-16-33)
Compound ZSQ-16-22 (399 mg, 1.71 mmol) was dissolved in a mixed solution of 4 ml of THF and 4 ml of H 2 O, lithium hydroxide monohydrate (5.15 mmol, 216 mg) was added, and the mixture was stirred at room temperature for 4 h. After the reaction was completed, 2N hydrochloric acid was added for acidification, concentrated to remove THF, separated and purified by C18 reverse-phase column chromatography, eluted with H 2 O/CH 3CN (4:1) to obtain 286 mg of white solid with a combined yield of 82%.
References:
WO2021/254254,2021,A1 Location in patent:Paragraph 35-36
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103-82-2
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![5-benzyl-1,2,4-oxadiazole-3-carboxylic Acid](/CAS/20200611/GIF/19706-09-3.gif)
19706-09-3
4 suppliers
inquiry