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5-BETA-DIHYDRO-17-HYDROXYPROGESTERONE synthesis

3synthesis methods
-

Yield:570-58-1 77%

Reaction Conditions:

with pyridine;palladium 10% on activated carbon;hydrogen in 1,4-dioxane;ethanol at 30; for 17 h;

References:

De Ravel, Marc Rolland;Alameh, Ghina;Melikian, Maxime;Mahiout, Zahia;Emptoz-Bonneton, Agnès;Matera, Eva-Laure;Lomberget, Thierry;Barret, Roland;Rocheblave, Luc;Walchshofer, Nadia;Beltran, Sonia;El Jawad, Lucienne;Mappus, Elisabeth;Grenot, Catherine;Pugeat, Michel;Dumontet, Charles;Le Borgne, Marc;Cuilleron, Claude Yves [Journal of Medicinal Chemistry,2015,vol. 58,# 4,p. 1832 - 1845] Location in patent:supporting information