ChemicalBook CAS DataBase List 5-Bromo-1,3-dichloro-2-fluorobenzene

5-Bromo-1,3-dichloro-2-fluorobenzene synthesis

6synthesis methods

Product Name:5-Bromo-1,3-dichloro-2-fluorobenzene
CAS Number:17318-08-0
Molecular formula:C6H2BrCl2F
Molecular Weight:243.89

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Yield:17318-08-0 83.1%

Reaction Conditions:

Stage #1: 5-bromo-3-chloro-2-fluoroanilinewith hydrogenchloride;sodium nitrite in water at 10;
Stage #2: with hydrogenchloride;copper(l) chloride in water at 50; for 5 h;

Steps:

3 Preparation of 3,5-dichloro-4-fluorobromobenzene

Put 224.5g (1mol) of 2-fluoro-3-chloro-5-bromoaniline, 608g (5mol) of hydrochloric acid and 300g of water into a 2L four-necked flask, cool to 10, and add 103.5g (1.5mol) of sodium nitrite dropwise. A solution of 200 g of water is dripped to obtain a diazonium liquid. Put 300g of hydrochloric acid and 100g of cuprous chloride into another 2L four-necked flask, raise the temperature to 50°C, add step diazonium solution dropwise, keep it at this temperature for 5h after dropping, control the sampling, the reaction is complete, cool to room temperature, and let it rest. The layers were separated, the oil layer was neutralized, washed with water, separated into layers, distilled, and then rectified to obtain 203 g of 3,5-dichloro-4-fluorobromobenzene with a purity of 99.8% and a yield of 83.1%.

References:

CN112010732,2020,A Location in patent:Paragraph 0047-0052