ChemicalBook CAS DataBase List 5-BROMO-1,3-DIMETHYL-6-PHENYLURACIL

5-BROMO-1,3-DIMETHYL-6-PHENYLURACIL synthesis

3synthesis methods

Product Name:5-BROMO-1,3-DIMETHYL-6-PHENYLURACIL
CAS Number:98854-09-2
Molecular formula:C12H11BrN2O2
Molecular Weight:295.13

7033-39-8
58 suppliers
$65.00/1g

591-50-4 Synthesis

591-50-4
472 suppliers
$10.00/1g

2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-phenyl-

42542-99-4
0 suppliers
inquiry

98854-09-2
10 suppliers
inquiry

Yield:98854-09-2 39% ，42542-99-4 23%

Reaction Conditions:

with copper(I) bromide;lithium tert-butoxide in N,N-dimethyl-formamide; for 1 h;Reflux;regioselective reaction;

Steps:

1 General procedure for the CuBr catalyzed C-H bond activation for arylation

General procedure: To a mixture of 1,3-dimethyluracil (0.140 g, 1 mmol), CuBr (0.057 g, 0.4 mmol, 0.4 equiv), and the aryl iodide (2 mmol, 2 equiv) in DMF (2 mL) was added LiO^tBu (0.320 g, 4 mmol, 4 equiv). The reaction mixture was heated at reflux temperature for 1 h. After cooling to the room temperature, the reaction was quenched by adding saturated aqueous NH₄Cl solution.The solvent was removed under reduced pressure. The residue was partitioned between EtOAc and H₂O. The organic layer was washed with saturated aqueous NaCl solution, dried over anhydrous MgSO₄, and then concentrated under reduced pressure to dryness. The residue was purified by flash column chromatography to give the product.

References:

Cheng, Chien;Shih, Yu-Chiao;Chen, Hui-Ting;Chien, Tun-Cheng [Tetrahedron,2013,vol. 69,# 4,p. 1387 - 1396]

77-78-1
293 suppliers
$22.00/25g

2,4(1H,3H)-Pyrimidinedione,5-bromo-6-phenyl-

16290-56-5
0 suppliers
inquiry

98854-09-2
10 suppliers
inquiry

References

2,4(1H,3H)-Pyrimidinedione,5,6-dibromo-1,3-dimethyl-

79462-73-0
0 suppliers
inquiry

71-43-2
676 suppliers
$11.19/25ML

98854-09-2
10 suppliers
inquiry

Dibenzo[f,h]quinazoline-2,4(1H,3H)-dione, 1,3-dimethyl-

51209-65-5
0 suppliers
inquiry

References