5-bromo-1-nitro-naphthalene synthesis
- Product Name:5-bromo-1-nitro-naphthalene
- CAS Number:5328-76-7
- Molecular formula:C10H6BrNO2
- Molecular Weight:252.06
86-57-7
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5328-76-7
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Yield:5328-76-7 42%
Reaction Conditions:
with ferric(III) chloride;bromine at 90; for 3 h;
Steps:
5.1 A compound represented by [Formula 5-a] was synthesized by the following [Scheme 13].
In a dried 500 mL reactor, 1-nitronaphthalene 100 g (577 mmol) and iron chloride 90 g (58 mmol) were added, and the temperature was raised to 90°C. Then, bromine 93.3 g (577 mmol) was slowly dropped and stirred for 3 hours. .When the reaction was complete, extraction was performed with ethyl acetate and water, the organic layer was concentrated under reduced pressure, and then separated by column chromatography to obtain 61 g of a compound represented by [Formula 5-a]. (Yield 42%)
References:
KR2015/43571,2015,A Location in patent:Paragraph 0390-0396
3272-91-1
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5328-76-7
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$5.00/100mg