![](/CAS/GIF/883230-68-0.gif)
5-BROMO-2-(1H-IMIDAZOL-1-YL)PYRIMIDINE synthesis
- Product Name:5-BROMO-2-(1H-IMIDAZOL-1-YL)PYRIMIDINE
- CAS Number:883230-68-0
- Molecular formula:C7H5BrN4
- Molecular Weight:225.05
![Imidazole](/CAS/GIF/288-32-4.gif)
288-32-4
990 suppliers
$5.00/25g
![5-BROMO-2-FLUOROPYRIMIDINE](/CAS/GIF/62802-38-4.gif)
62802-38-4
185 suppliers
$10.00/1g
![5-BROMO-2-(1H-IMIDAZOL-1-YL)PYRIMIDINE](/CAS/GIF/883230-68-0.gif)
883230-68-0
33 suppliers
$45.00/100mg
Yield:883230-68-0 95%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 70; for 24 h;Schlenk technique;
Steps:
Preparation of Substrates; General Procedure
General procedure: 5-Bromo-2-fluoropyridine (0.5 mmol), an N-heterocyclic amine (1.0 mmol) and K2CO3 (1.0 mmol) were added to a 25-mL Schlenk tube, followed by addition of DMSO (2 mL). The reaction mixture was heated to 70 °C for 24 h under air atmosphere. Then, the reaction mixture was added to brine (15 mL) and this mixture was extracted with CH2Cl2 (3 × 15 mL). The combined extracts were concentrated under reduced pressure and the product was isolated by flash chromatography on a silica gel (200-300 mesh) column.
References:
Tao, Sheng;Ji, Enhui;Shi, Lei;Liu, Ning;Xu, Liang;Dai, Bin [Synthesis,2017,vol. 49,# 23,p. 5120 - 5130]
![Imidazole](/CAS/GIF/288-32-4.gif)
288-32-4
990 suppliers
$5.00/25g
![5-Bromo-2-chloropyrimidine](/CAS/GIF/32779-36-5.gif)
32779-36-5
624 suppliers
$5.00/5g
![5-BROMO-2-(1H-IMIDAZOL-1-YL)PYRIMIDINE](/CAS/GIF/883230-68-0.gif)
883230-68-0
33 suppliers
$45.00/100mg
![Imidazole](/CAS/GIF/288-32-4.gif)
288-32-4
990 suppliers
$5.00/25g
![5-Bromo-2-iodopyrimidine](/CAS/GIF/183438-24-6.gif)
183438-24-6
384 suppliers
$6.00/1g
![5-BROMO-2-(1H-IMIDAZOL-1-YL)PYRIMIDINE](/CAS/GIF/883230-68-0.gif)
883230-68-0
33 suppliers
$45.00/100mg