5'-Bromo-2',6-difluorobiphenyl-2-carbonitrile synthesis

13synthesis methods

Product Name:5'-Bromo-2',6-difluorobiphenyl-2-carbonitrile
CAS Number:425379-21-1
Molecular formula:C13H6BrF2N
Molecular Weight:294.09

1435-53-6 Synthesis

1435-53-6
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425379-16-4
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5'-Bromo-2',6-difluorobiphenyl-2-carbonitrile

425379-21-1
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Yield:425379-21-1 30%

Reaction Conditions:

Stage #1: 2,4-dibromo-1-fluorobenzenewith isopropylmagnesium chloride
Stage #2:
Stage #3: 2-bromo-3-fluorobenzonitrile;tris(dibenzylideneacetone)dipalladium ⁽⁰⁾;tri-tert-butyl phosphine in tetrahydrofuran at 23; for 1 h;

References:

Gauthier Jr., Donald R.;Limanto, John;Devine, Paul N.;Desmond, Richard A.;Szumigala Jr., Ronald H.;Foster, Bruce S.;Volante [Journal of Organic Chemistry,2005,vol. 70,# 15,p. 5938 - 5945]

862423-48-1 Synthesis

[1,1'-Biphenyl]-2-carbonitrile, 2',6-difluoro-

862423-48-1
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425379-21-1
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References

[1,1'-Biphenyl]-2-carbonitrile, 5'-amino-2',6-difluoro-

425379-18-6
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425379-21-1
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References

425379-16-4
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425379-21-1
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References

403-54-3 Synthesis

403-54-3
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425379-21-1
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References