5-Bromo-2-hydrazino-3-nitropyridine synthesis

Yield:15862-42-7 89%

Reaction Conditions:

with hydrazine hydrate in methanol at 20;Cooling;

Steps:

4.1. General procedure for the synthesis of compounds 2a-d

General procedure: A solution of an appropriate 2-chloropyridine (5 mmol) in methanol (15 mL) was added dropwise to a pre-cooled solution of hydrazine hydrate (2.42 mL, 50 mmol, 10 eq.) in methanol (10 mL). (2d was added in small portions as a suspension due to low solubility). The reaction mixture was stirred at room temperature for1-2 h until the starting compound was completely consumed (TLC). The precipitate was filtered off, washed with water and dried on air.

References:

Bastrakov, Maxim A.;Nikol'skiy, Vladislav V.;Starosotnikov, Alexey M.;Fedyanin, Ivan V.;Shevelev, Svyatoslav A.;Knyazev, Daniil A. [Tetrahedron,2019,vol. 75,# 47,art. no. 130659]