5-Bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile synthesis
- Product Name:5-Bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile
- CAS Number:814262-90-3
- Molecular formula:C14H12O4
- Molecular Weight:244.24
![Benzoic acid, 5-[[(4-methylphenyl)sulfonyl]oxy]-2-(phenylmethoxy)-, methyl ester](/CAS/20210305/GIF/1285516-29-1.gif)
1285516-29-1
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Yield:-
Reaction Conditions:
Stage #1: methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoatewith water;potassium hydroxide in ethanol;Reflux;
Stage #2: with hydrogenchloride in water;ethyl acetate;Product distribution / selectivity;
Steps:
38.C
Methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 75; 22.0 g, 53.3 mmol) was boiled with potassium hydroxide (20.95 g, 373 mmol) in a mixture of ethanol (320 ml) and water (80 ml) overnight. After the ethanol had been evaporated, the aqueous solution was washed with ethyl acetate (500 mi), and then acidified with concentrated HCI. The mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over sodium sulfate, and evaporated in vacuo to yield the title compound as a yellow oil. 14 g.MS (electrospray): m/z [MH+ 23]+ = 267
References:
WO2011/38572,2011,A1 Location in patent:Page/Page column 60
2150-46-1
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$6.00/1g
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100-39-0
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$10.00/10g
814262-90-3
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![Benzoic acid, 2-hydroxy-5-[[(4-methylphenyl)sulfonyl]oxy]-, methyl ester](/CAS/20210305/GIF/94033-94-0.gif)
94033-94-0
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814262-90-3
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