5-bromo-2-methylsulfanyl-3H-pyrimidin-4-one synthesis

Yield: 87%

Reaction Conditions:

with N-Bromosuccinimide in dichloromethane for 6 h;Reflux;

Steps:

1.2 Example 1
Step 2, Preparation of 5-bromo-2-methylthio-4-pyrimidinone: Take 142 g of 2-methylthio-4-pyrimidinone, dissolve in 500 ml of methylene chloride, add NBS 190 g, reflux for 6 hours, After the reaction is completed, cool to room temperature, filter, wash the filtrate, organicThe phase was dried and recrystallized on an ice bath to give 190 g of a pale yellow solid in a yield of 87%.

References:

Shanghai Weiju Industrial Co., Ltd.;Liu Hui CN107488175, 2017, A Location in patent:Paragraph 0008; 0010