5-Bromo-2-pyridinecarbonitrile synthesis
- Product Name:5-Bromo-2-pyridinecarbonitrile
- CAS Number:97483-77-7
- Molecular formula:C6H3BrN2
- Molecular Weight:183.01
90145-48-5
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$31.00/250 mg
97483-77-7
548 suppliers
$10.00/5g
Yield:97483-77-7 43.6 g
Reaction Conditions:
with trichlorophosphate in toluene for 2 h;Reflux;
Steps:
9 Description 9: 5-bromopicolinonitrile (D9)
Phosphorus oxychloride (111 g, 0.720 mol) was added to a mixture of 5-bromopicolinamide (D8) (58 g, 0.288 mol) in dry toluene (300 ml) The mixture was heated to reflux for 2 hours. The mixture was poured into ice/water, and basified to pH=12 with 2N NaOH. The resulting mixture was extracted with ethyl acetate and the organic phase was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture petroleum ether/ethyl acetate 10:1. Collected fractions, after solvent evaporation afforded the title compound (D9) (43.6 g) as a yellow solid.
References:
Borriello, Manuela;Rovati, Lucio;Stasi, Luigi Piero;Buzzi, Benedetta;Colace, Fabrizio US2013/261100, 2013, A1 Location in patent:Paragraph 0282-0283
624-28-2
713 suppliers
$5.00/5g
97483-77-7
548 suppliers
$10.00/5g
31181-90-5
332 suppliers
$5.00/250mg
97483-77-7
548 suppliers
$10.00/5g