5-BroMo-2-(pyrrolidin-1-yl)benzonitrile synthesis
- Product Name:5-BroMo-2-(pyrrolidin-1-yl)benzonitrile
- CAS Number:876918-66-0
- Molecular formula:C11H11BrN2
- Molecular Weight:251.12
123-75-1
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Yield:876918-66-0 97.3%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 86; for 6 h;
Steps:
7.1
II1 (1.0 g, 5 mmol) was dissolved in DMF (15 mL)K2CO3 (2.0 g, 15 mmol), tetrahydropyrrole (1.0 g, 15 mmol)The response was complete at 6C for 6 h at 86 ° C. Add 80 mL of water to dilute,Ethyl acetate (80 mL x 3), washed with saturated brine, dried over anhydrous magnesium sulfate,The solvent was evaporated under reduced pressure to give 1.1 g of an orange solid, 5-bromo-2-tetrahydropyrrole-benzonitrile (III7) in a yield of 97.3%.
References:
CN106632245,2017,A Location in patent:Paragraph 0094