5-BROMO-4,6-DIMETHYLNICOTINIC ACID synthesis
- Product Name:5-BROMO-4,6-DIMETHYLNICOTINIC ACID
- CAS Number:93350-01-7
- Molecular formula:C8H8BrNO2
- Molecular Weight:230.06
63644-86-0
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93350-01-7
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Yield:93350-01-7 79%
Reaction Conditions:
with water;potassium hydroxide at 110; for 16 h;
Steps:
36.D Step D: 5-bromo-4,6-dimethylnicotinic acid
To a mixture of 5-bromo-4,6-dimethylnicotinonitrile (10 g, 47.4 mmol) in water (20 mL) was added KOH (26.6 g, 47.4 mmol). The reaction was stirred at about 110 °C for about 16 h. The reaction mixture was then cooled to ambient temperature and was neutralized by the addition of concentrated HC1. The resulting solid was filtered to provide 5-bromo-4,6-dimethylnicotinic acid (9 g, 79 %). LCMS (Table 1 , Method e) RT= 1.61 min.; MS m/z = 232, 233 (M+H).
References:
WO2016/198908,2016,A1 Location in patent:Page/Page column 77
23819-87-6
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93350-01-7
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42951-71-3
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93350-01-7
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