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778611-65-7

5-BroMo-4-(broMoMethyl)-2-chloropyridine synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 70 percent / bromine; acetic acid / 3 h / 50 °C
2.1: sodium nitrite; concd. hydrochloric acid / 1 h / -20 °C
2.2: 48 percent / aq. sodium hydroxide / 0 - 5 °C / pH 11
3.1: 47 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / Heating

References:

Cheng, Jie;Xu, Liang;Stevens, Edwin D.;Trudell, Mark L.;Izenwasser, Sari;Wade, Dean [Journal of Heterocyclic Chemistry,2004,vol. 41,# 4,p. 569 - 574]

778611-64-6 Synthesis
5-BROMO-2-CHLORO-4-PICOLINE

778611-64-6
234 suppliers
$6.00/1g

5-BroMo-4-(broMoMethyl)-2-chloropyridine

778611-65-7
11 suppliers
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