![](/CAS/20180703/GIF/1220039-87-1.gif)
5-Bromo-4-chloro-pyrimidine hydrochloride synthesis
- Product Name:5-Bromo-4-chloro-pyrimidine hydrochloride
- CAS Number:1220039-87-1
- Molecular formula:C4H3BrCl2N2
- Molecular Weight:229.89
70850-67-8
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![5-Bromo-4-chloro-pyrimidine hydrochloride](/CAS/20180703/GIF/1220039-87-1.gif)
1220039-87-1
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Yield:-
Reaction Conditions:
with trichlorophosphate at 90; for 1 h;
Steps:
A suspension of 5-bromopyrimidone hydrobromide (1.0 g, 3.9 mmol) in phosphorous oxychloride (4 mL) was heated at 90 0C for 1 h then cooled 0 0C. The mixture was filtered, washed with POCI3 (2 x 2 mL) to furnish the title compound as a cream solid(388 mg). This compound was unstable to air and was used immediately in the next step.
References:
WO2010/41054,2010,A1 Location in patent:Page/Page column 39-40