5-broMo-6-ethoxy-3-nitropyridin-2-aMine synthesis
- Product Name:5-broMo-6-ethoxy-3-nitropyridin-2-aMine
- CAS Number:239791-62-9
- Molecular formula:C7H8BrN3O3
- Molecular Weight:262.06
40851-82-9
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Yield:239791-62-9 80%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 0 - 20; for 2 h;
Steps:
17.2 Step 2: 5-bromo-6-ethoxy-3-nitropyridin-2-amine
To 6-ethoxy-3-nitropyridin-2-amine (3.0 g, 16.4 mmol) was added 30 mL of DMF. The mixture was cooled to 0 °C. NBS (3.2 g, 18.04 mmol) was added to the above cooled mixture in portions. The new mixture was slowly warmed to room temperature and stirred for 2 h. The mixture was diluted with water and extracted with EtOAc. The combined organic layers were washed with aq. Na 2S 2O 3 solution, dried, filtered and concentrated. The residue was purified by silica gel column chromatography (PE : EtOAc = 3 : 1) to afford the title product (3.4 g, 80% yield). LC-MS (M+H) + = 262.0, 264.0.
References:
WO2021/244608,2021,A1 Location in patent:Page/Page column 64
27048-04-0
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