ChemicalBook CAS DataBase List 5-Bromo-8-methylquinoxaline

5-Bromo-8-methylquinoxaline synthesis

2synthesis methods

Product Name:5-Bromo-8-methylquinoxaline
CAS Number:1360599-43-4
Molecular formula:C9H7BrN2
Molecular Weight:223.07

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Yield:1360599-43-4 41%

Reaction Conditions:

with N-Bromosuccinimide in acetonitrile at 60; for 16 h;

Steps:

5-Bromo-8-methylquinoxaline:

To a solution of 5-methylquinoxaline (9.50 g, 65.97 minol) in CH3CN (80 mL) was added 1-bromopyrrolidine-2,5-dione (27.00 g, 151.74 minol) at room temperature. The resulting solution was stirred for 16 h at 60 °C. After cooling to room temperature, the reactionminxture was concentrated under reduced pressure and the residue was diluted with ethyl acetate (500 mL). The insoluble solids in theminxture were filtered out and the filtrate was washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure to yield 5-bromo-8-methylquinoxaline as brown solid (6.00 g, 41%). MS: m/z = 222.9 [M+Hj .

References:

WO2017/106607,2017,A1 Location in patent:Paragraph 00217; 00218

4-BROMO-7-METHYL-BENZO[1,2,5]THIADIAZOLE

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References