5-BROMO-N3-METHYL-PYRAZINE-2,3-DIAMINE synthesis
- Product Name:5-BROMO-N3-METHYL-PYRAZINE-2,3-DIAMINE
- CAS Number:55635-63-7
- Molecular formula:C5H7BrN4
- Molecular Weight:203.04
24241-18-7
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74-89-5
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55635-63-7
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$87.59/250mg
Yield: 81%
Reaction Conditions:
in water at 100;Sealed tube;
Steps:
12.1 Step 1: Synthesis of 6-bromo-N2-methylpyrazine-2,3-diamine (12-b)
A solution of 3,5-dibromopyrazin-2-amine (12-a) (3 g, 11.96 mmol) in MeNH2/THF (2 M) (30 mL) was stirred in a sealed tube at 100 °C overnight. The mixture was concentrated and was purified (silica gel; eluting with ethyl acetate:Petroleum ether =1:2) to afford compound 12-b (1.96 g, 81%) as a white solid.1H NMR (400 MHz, Chloroform-d) d 7.46 (s, 1H), 4.49 (s, 1H), 3.03 (d, J = 3.9 Hz, 3H). LCMS Mass: 203 (M++H).
References:
GB002, INC.;LOPEZ, Luis;COBURN, Craig;ROWBOTTOM, Martin W.;BOTROUS, Iriny;KASEM, Michelle WO2020/264420, 2020, A1 Location in patent:Page/Page column 196; 197
67-56-1
739 suppliers
$7.29/5ml-f
24241-18-7
417 suppliers
$6.00/5g
74-89-5
7 suppliers
$13.44/25ML
55635-63-7
50 suppliers
$87.59/250mg