(5-BROMO-PYRIMIDIN-2-YL)-DIETHYL-AMINE synthesis
- Product Name:(5-BROMO-PYRIMIDIN-2-YL)-DIETHYL-AMINE
- CAS Number:433684-23-2
- Molecular formula:C8H12BrN3
- Molecular Weight:230.1
Yield:433684-23-2 95.8%
Reaction Conditions:
in tetrahydrofuran at 80; for 3 h;Inert atmosphere;
Steps:
4.25.1 Step 1 5-bromo-N,N-diethylpyrimidin-2-amine
A solution of 5-bromo-2-chloropyrimidine (1.0 g, 5.17 mmol) and diethylamine (2.13 mL, 20.68 mmol) in THF (5 mL) was stirred at 80 oC for 3 hrs. The mixture was cooled and concentrated to dryness to give the crude product, which was purified by chromatography (eluted with PE: EA = 100: 1) to give 5-bromo-N,N-diethylpyrimidin-2-amine (1.14 g, 95.8% yield) as a yellow solid. Retention time (LC-MS): 1.827 min. MH+ 231.
References:
WO2016/44792,2016,A1 Location in patent:Page/Page column 118
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