ChemicalBook CAS DataBase List 5-bromonaphtho[1,2-b]benzofuran

5-bromonaphtho[1,2-b]benzofuran synthesis

4synthesis methods

Product Name:5-bromonaphtho[1,2-b]benzofuran
CAS Number:1256544-17-8
Molecular formula:C16H9BrO
Molecular Weight:297.15

239-30-5
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Yield:1256544-17-8 82%

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide at 60; for 5 h;

Steps:

E.E-3

(E-3) Synthesis of 5-bromobenzo[b]naphtho[2,1-d]furan 32.7g of benzo[b]naphtho[2,1-d]furan was dissolved in 300 mL of N,N-dimethylformamide. Then, 50 mL of a N,N-dimethylformamide solution of 28.0g of N-bromosuccinimide was added, and the resulting reaction solution was stirred with heating at 60°C for 5 hours. After cooling to room temperature, the reaction solution was poured in 2L of water. Solids thus obtained were sequentially washed with methanol, water and methanol. The resulting crude product was purified by means of silica gel column chromatography, whereby 36.5g (yield: 82%) of 5-bromobenzo[b]naphtho[2,1-d]furan was obtained.

References:

EP2436679,2012,A1 Location in patent:Page/Page column 50

90-15-3 Synthesis

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References

1165952-91-9
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References

Benzo[b]naphtho[2,1-d]furan, 7,8,9,10-tetrahydro-

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References