![](/CAS/20150408/GIF/88987-42-2.gif)
5-BROMOPENTANOIC ACID, T-BUTYL ESTER synthesis
- Product Name:5-BROMOPENTANOIC ACID, T-BUTYL ESTER
- CAS Number:88987-42-2
- Molecular formula:C9H17BrO2
- Molecular Weight:237.13
![5-Bromovaleryl chloride](/CAS/GIF/4509-90-4.gif)
4509-90-4
228 suppliers
$15.00/1g
![tert-Butanol](/CAS/GIF/75-65-0.gif)
75-65-0
740 suppliers
$10.00/10ml
![5-BROMOPENTANOIC ACID, T-BUTYL ESTER](/CAS/20150408/GIF/88987-42-2.gif)
88987-42-2
70 suppliers
$9.00/100mg
Yield: 3.02 g
Reaction Conditions:
with oxalyl dichloride in dichloromethane at 0 - 20;
Steps:
1.ED.3 Step 3: tert-Butyl 5-bromopentanoate
To a solution of 5-bromovaleric acid (2.5 g, 14.0 mmol) in dichloromethane (10 mL) was added oxalyl chloride (1.15 mL, 13.2 mmol) and the reaction mixture stirred at room temperature for 4 hours. The solvent and excess oxalyl chloride were removed under vacuum. The crude acid chloride was dissolved in dichloromethane (10 mL) and cooled to 0°C. Then fert-butanol (10 mL) was added and the reaction mixture stirred at room temperature overnight. The solvent was removed, and the crude was purified by flash chromatography (SiCh: ethyl acetate/hexane 0 to 50%) to get fert-butyl 5-bromopentanoate (3.02 g, 92%) as a colorless oil. 1H NMR (300 MHz, CDCl3) δ: 3.40 (t, 2H, J = 6.6 Hz); 2.24 (t, 2H, J = 7.3 Hz); 1.90-1.81 (m, 2H); 1.75-1.69 (m, 2H); 1.43 (s, 9H).
References:
MODERNATX, INC.;BENENATO, Kerry E.;BUTCHER, William WO2018/232120, 2018, A1 Location in patent:Paragraph 001036
![5-Bromovaleric acid](/CAS/GIF/2067-33-6.gif)
2067-33-6
376 suppliers
$6.00/5g
![tert-Butanol](/CAS/GIF/75-65-0.gif)
75-65-0
740 suppliers
$10.00/10ml
![5-BROMOPENTANOIC ACID, T-BUTYL ESTER](/CAS/20150408/GIF/88987-42-2.gif)
88987-42-2
70 suppliers
$9.00/100mg
![5-Bromovaleric acid](/CAS/GIF/2067-33-6.gif)
2067-33-6
376 suppliers
$6.00/5g
![Isobutylene](/CAS/GIF/115-11-7.gif)
115-11-7
229 suppliers
$45.00/25 g
![5-BROMOPENTANOIC ACID, T-BUTYL ESTER](/CAS/20150408/GIF/88987-42-2.gif)
88987-42-2
70 suppliers
$9.00/100mg
![tert-Butanol](/CAS/GIF/75-65-0.gif)
75-65-0
740 suppliers
$10.00/10ml
![5-BROMOPENTANOIC ACID, T-BUTYL ESTER](/CAS/20150408/GIF/88987-42-2.gif)
88987-42-2
70 suppliers
$9.00/100mg
![5-Bromovaleric acid](/CAS/GIF/2067-33-6.gif)
2067-33-6
376 suppliers
$6.00/5g
![2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA](/CAS/GIF/71432-55-8.gif)
71432-55-8
135 suppliers
$6.00/250mg
![5-BROMOPENTANOIC ACID, T-BUTYL ESTER](/CAS/20150408/GIF/88987-42-2.gif)
88987-42-2
70 suppliers
$9.00/100mg