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ChemicalBook CAS DataBase List 5-BROMOQUINOLIN-2-AMINE
347146-12-7

5-BROMOQUINOLIN-2-AMINE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: trichlorophosphate / 2 h / Reflux; Inert atmosphere
2: ethanol; toluene / 0.75 h / Inert atmosphere; Microwave irradiation; Heating
3: trifluoroacetic acid / 1.5 h / 60 °C / Inert atmosphere

References:

Cheng, Yuan;Judd, Ted C.;Bartberger, Michael D.;Brown, James;Chen, Kui;Fremeau Jr., Robert T.;Hickman, Dean;Hitchcock, Stephen A.;Jordan, Brad;Li, Vivian;Lopez, Patricia;Louie, Steven W.;Luo, Yi;Michelsen, Klaus;Nixey, Thomas;Powers, Timothy S.;Rattan, Claire;Sickmier, E. Allen;St. Jean Jr., David J.;Wahl, Robert C.;Wen, Paul H.;Wood, Stephen [Journal of Medicinal Chemistry,2011,vol. 54,# 16,p. 5836 - 5857]

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