5-BroMothiophene-2,3-dicarbaldehyde synthesis

Yield:-

Reaction Conditions:

with bromine in chloroform at 20;

Steps:

1 Synthesis of 5Brorno2,3hiophenedicarboxa1dehyde (1):
Bromine (6.0 rnL, 1163 mmoi) was added drop wise at room temperature to a solution of 2,3- thiophenedicarboxaldehyde (5ig, 3638 mmol) in 100 rnL of CHC13. The reaction mixture was stirred overnight and then excess bromine was quenched with a saturated solution of Na2S2O3. The organic layer was extracted with CHCI3, dried over Na2SO1 and volatiles were removed in vueno to obtain 1 as a brown solid. Spectroscopically pure compound was isolated by column chromatography using silica gel as stationary phase and a 4: 1 mixture of CH1Cl1 :hexanes. ‘H NMR (500 MHz, CDCI3): 51 037 (s, 1H), 1026 (s, 1H), 759 (s, 1H).

References:

SABIC GLOBAL TECHNOLOGIES B.V.;AL-RAFIA, S. M. Ibrahim;HAUGER, Tate C.;BURIAK, Jillian M.;TEVTIA, Amit WO2015/166360, 2015, A1 Location in patent:Paragraph 0058