5-(but-2-ynyloxy)pyrazine-2-carboxylic acid synthesis
1synthesis methods
- Product Name:5-(but-2-ynyloxy)pyrazine-2-carboxylic acid
- CAS Number:1221447-98-8
- Molecular formula:C9H8N2O3
- Molecular Weight:192.17
Yield:1221447-98-8 27%
Reaction Conditions:
with potassium tert-butylate in N,N-dimethyl-formamide at 65; for 8 h;
References:
Hilpert, Hans;Guba, Wolfgang;Woltering, Thomas J.;Wostl, Wolfgang;Pinard, Emmanuel;Mauser, Harald;Mayweg, Alexander V.;Rogers-Evans, Mark;Humm, Roland;Krummenacher, Daniela;Muser, Thorsten;Schnider, Christian;Jacobsen, Helmut;Ozmen, Laurence;Bergadano, Alessandra;Banner, David W.;Hochstrasser, Remo;Kuglstatter, Andreas;David-Pierson, Pascale;Fischer, Holger;Polara, Alessandra;Narquizian, Robert [Journal of Medicinal Chemistry,2013,vol. 56,# 10,p. 3980 - 3995] Location in patent:supporting information