5-CHLORO-1,2,3,4-TETRAHYDRO-QUINOLIN-8-OL synthesis

Yield:54810-34-3 97%

Reaction Conditions:

with hydrogen in water at 20; under 760.051 Torr; for 0.666667 h;

Steps:

4

The 100mmol 5-chloro-8-hydroxyquinoline and load 0.6mmol platinum polymer microsphere catalyst Poly (DVB-co-HPMA) Pt and 500 ml of water are added in a reaction kettle, to hydrogen replaces the cauldron five times the air in, and then filled with hydrogen, the reaction at normal temperature and pressure 40 minutes, the aqueous phase is extracted three times with ethyl ether, the merger ether level, ethyl ether evaporate after drying, to obtain 5-chloro-8-hydroxy -1, 2, 3, 4-tetrahydro-quinoline, yield 97%.

References:

CN105884684,2016,A Location in patent:Paragraph 0022; 0023