5-chloro-2,3-dihydro-1-benzofuran synthesis

6synthesis methods

Product Name:5-chloro-2,3-dihydro-1-benzofuran
CAS Number:76429-69-1
Molecular formula:C8H7ClO
Molecular Weight:154.59

496-16-2 Synthesis

496-16-2
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$7.00/5g

76429-69-1
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$52.00/250mg

Yield:76429-69-1 96%

Reaction Conditions:

with N-chloro-succinimide;2,2,6,6-tetramethylpiperidin-1-oxoammonium trifluoromethanesulfonate in chloroform at 25; for 12 h;Schlenk technique;Reagent/catalyst;

Steps:

16.a-16.b

b) Take a 25mL Schlenk reaction tube and add 60.1mg of 2,3-dihydrobenzofuran, 79.8mg of N-chlorosuccinimide, 30.1mg of [TEMPO][OTf], 2mL of chloroform, and stir at 25 12 hours.After the reaction, the solvent was removed by rotary evaporation and column chromatography was separated to obtain 74.8 mg of 5-chloro-2,3-dihydrobenzofuran with a yield of 96%.

References:

CN112573978,2021,A Location in patent:Paragraph 0141-0145