5-CHLORO-2-FLUORO-4-METHOXYPHENYLBORONIC ACID synthesis
- Product Name:5-CHLORO-2-FLUORO-4-METHOXYPHENYLBORONIC ACID
- CAS Number:677741-96-7
- Molecular formula:C7H7BClFO3
- Molecular Weight:204.39
677741-99-0
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Yield:677741-96-7 53%
Reaction Conditions:
Stage #1: 1-chloro-4-fluoro-2-iodo-5-methoxy-benzenewith n-butyllithium;boron hydroxide in tetrahydrofuran;hexane at -78 - 20;
Stage #2: with hydrogenchloride at 20; for 1 h;
References:
WO2004/31189,2004,A1 Location in patent:Page 79