5-CHLORO-2-ISOBUTOXYBENZALDEHYDE synthesis

Yield:-

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 90; for 2 h;

Steps:

General Procedure for O-alylation (Procedure 1f).

General procedure: To a mixture of 5-chloro-2-hydroxybenzaldehyde (1.0 equiv) and K₂CO₃ (2.0 equiv) in dimethylformamide, alkylbromide (2.0 equiv) was added. After stirring at 90 °C for 2 h, the mixture was quenched by water and extracted with EtOAc twice. The combined organic mixture was washed with water and brine, dried over MgSO₄ and concentrated in vacuo and the residue was purified by silica gel column chromatography with hexane/EtOAc as eluent to afford a desired product.

References:

Ann, Jihyae;Do, Nayeon;Hwang, Inhwa;Lee, Jeewoo;Yu, Je-Wook;Zuo, Dongxu [Bioorganic and Medicinal Chemistry Letters,2022,vol. 65,art. no. 128693] Location in patent:supporting information