5-Chloro-2-methoxy-benzoic acid hydrazide synthesis
- Product Name:5-Chloro-2-methoxy-benzoic acid hydrazide
- CAS Number:33977-11-6
- Molecular formula:C8H9ClN2O2
- Molecular Weight:200.62
68216-06-8
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Yield:33977-11-6 85%
Reaction Conditions:
with hydrazine hydrate in ethanol; for 24 h;Reflux;Inert atmosphere;
Steps:
1
Then, the intermediate 2-1 (5-chloro-2-methoxybenzoylhydrazide) was synthesized according to the following procedure: 5.4 g (0.023 mmol) of ethyl 5-chloro-2-methoxybenzoate (250 mL) was added 90 mL of absolute ethanol and 3.6 mL of 80% hydrazine hydrate. The mixture was refluxed for 24 hours with N2 and extracted with methylene chloride to give a yellow oily liquid. The column was eluted with silica gel (CH2CI2 and petroleum ether) To give 3.9 g of a pale yellow solid in 85% yield.
References:
CN104277065,2016,B Location in patent:Paragraph 0097; 0100; 0102
3438-16-2
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33977-11-6
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33924-48-0
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33977-11-6
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