ChemicalBook CAS DataBase List 5-CHLORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

5-CHLORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE synthesis

5synthesis methods

Product Name:5-CHLORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
CAS Number:138035-68-4
Molecular formula:C8H6ClNO2
Molecular Weight:183.59

52130-17-3 Synthesis

52130-17-3
319 suppliers
$20.00/25g

79-04-9 Synthesis

79-04-9
353 suppliers
$12.00/5g

5-CHLORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

138035-68-4
23 suppliers
$223.66/1g

Yield:138035-68-4 94%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 50; for 15 h;

Steps:

Step 1: 5-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one

2-amino-3-chlorophenol (200 mg, 1.4 mmol), 2-chloroacetyl chloride (189 mg, 1.7 mmol) and K₂CO₃ (577 mg, 4.2 mmol) were dissolved in DMF (35 mL) and the mixture was stirred at 50° C for 15 h. The resulting suspension was filtered through a pad of solka floc and the solvent was concentrated. EtOAc and NaHCO3 sat. sol. were added and the organic phase was washed with H₂O, brine, dried over Na₂SO_4, filtered and concentrated in vacuo. The title compound was obtained as a yellow solid (240 mg, 94%). LCMS (ES+) m/z 184 (M+H)+, RT 1.2 min

References:

WO2021/28362,2021,A1 Location in patent:Page/Page column 144-145

87-65-0 Synthesis