5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID synthesis

Yield:380448-07-7 96%

Reaction Conditions:

Stage #1: 5-chloro-3-formyl-1H-indole-2-carboxylic acid ethyl esterwith water;lithium hydroxide in tetrahydrofuran at 20;
Stage #2: with hydrogenchloride in tetrahydrofuran;water;

References:

Yoshikawa, Kenji;Yokomizo, Aki;Naito, Hiroyuki;Haginoya, Noriyasu;Kobayashi, Shozo;Yoshino, Toshiharu;Nagata, Tsutomu;Mochizuki, Akiyoshi;Osanai, Ken;Watanabe, Kengo;Kanno, Hideyuki;Ohta, Toshiharu [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 24,p. 8206 - 8220] Location in patent:experimental part