5-Chloro-3-phenylbenzofuran-2-carboxaMide synthesis

Yield:26965-48-0 74%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 80 - 145; for 1 h;Microwave irradiation;

Steps:

General Procedure for the Synthesis ofBenzofuran-2-carboxamides 1-20

General procedure: The mixture of phenol (3 mmol), corresponding2-chloroacetamide (3.6 mmol), Cs₂CO₃ (7.5 mmol) in DMF (7mL) was placed into microwave oven (KMIC-1.5KW) and irradiated at 80 ^oCfor 30 min followed at 145 ^oC for 30 min. After the reaction mixturewas cooled to room temperature, the solvent of DMF was evaporated under reducedpressure and the residue was directly absorbed into silica gel to be purifiedby flash chromatography with CombiFlash automatic.

References:

Xie, Yong-Sheng;Kumar, Deepak;Bodduri, V.D. Vijaykumar;Tarani, P. Srivastava;Zhao, Bao-Xiang;Miao, Jun-Ying;Jang, Kiwan;Shin, Dong-Soo [Tetrahedron Letters,2014,vol. 55,# 17,p. 2796 - 2800] Location in patent:supporting information