5-Chloro-6-fluoropyrimidine-2,4-diamine synthesis
- Product Name:5-Chloro-6-fluoropyrimidine-2,4-diamine
- CAS Number:1353054-66-6
- Molecular formula:C4H4ClFN4
- Molecular Weight:162.55
696-82-2
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Yield:1353054-66-6 8.7 g
Reaction Conditions:
Stage #1: 2,4,6-trifluoropyrimidinewith ammonium hydroxide in acetonitrile at 0 - 40; for 12 h;
Stage #2: with N-chloro-succinimide in methanol;ethanol at 0 - 50; for 12 h;
References:
Perreault, Stephane;Chandrasekhar, Jayaraman;Cui, Zhi-Hua;Evarts, Jerry;Hao, Jia;Kaplan, Joshua A.;Kashishian, Adam;Keegan, Kathleen S.;Kenney, Thomas;Koditek, David;Lad, Latesh;Lepist, Eve-Irene;McGrath, Mary E.;Patel, Leena;Phillips, Bart;Therrien, Joseph;Treiberg, Jennifer;Yahiaoui, Anella;Phillips, Gary [Journal of Medicinal Chemistry,2017,vol. 60,# 4,p. 1555 - 1567]
696-83-3
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