![](/CAS/GIF/59962-89-9.gif)
5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:59962-89-9
- Molecular formula:C11H9ClO3
- Molecular Weight:224.64
Yield:59962-89-9 84.8%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide;acetonitrile; for 48 h;Reflux;
Steps:
1.1 Example 1
(1) 5-chlorosalicylaldehyde (10 mmol) and ethyl bromoacetate (13 mmol) were dissolved in a mixed solvent of MeCN-DMF (40 mL, 1:1 by volume), cesium carbonate (20 mmol) was added, and the reaction was refluxed for 48 hours. after the solid was removed by filtration, the filtrate was concentrated, diluted with ethyl acetate, washed successively with water, the organic layer was washed with saturated sodium chloride, combined, dried over anhydrous sodium sulfate, and concentrated,Recrystallization from ethanol gave colorless crystals (1.90 g, yield: 84.8%)That is, ethyl 5-chlorobenzofuran-2-carboxylate;
References:
CN110078720,2019,A Location in patent:Paragraph 0023-0025
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