ChemicalBook CAS DataBase List 5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER

5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER synthesis

8synthesis methods

Product Name:5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
CAS Number:59962-89-9
Molecular formula:C11H9ClO3
Molecular Weight:224.64

105-36-2 Synthesis

105-36-2
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635-93-8
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5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER

59962-89-9
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Yield:59962-89-9 84.8%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide;acetonitrile; for 48 h;Reflux;

Steps:

1.1 Example 1

(1) 5-chlorosalicylaldehyde (10 mmol) and ethyl bromoacetate (13 mmol) were dissolved in a mixed solvent of MeCN-DMF (40 mL, 1:1 by volume), cesium carbonate (20 mmol) was added, and the reaction was refluxed for 48 hours. after the solid was removed by filtration, the filtrate was concentrated, diluted with ethyl acetate, washed successively with water, the organic layer was washed with saturated sodium chloride, combined, dried over anhydrous sodium sulfate, and concentrated,Recrystallization from ethanol gave colorless crystals (1.90 g, yield: 84.8%)That is, ethyl 5-chlorobenzofuran-2-carboxylate;

References:

CN110078720,2019,A Location in patent:Paragraph 0023-0025

141-97-9 Synthesis