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1269695-63-7

5-chlorochroMan-3-carboxylic acid synthesis

2synthesis methods
2H-1-Benzopyran-3-carboxaldehyde, 5-chloro-

1269695-61-5
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5-chlorochroMan-3-carboxylic acid

1269695-63-7
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-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: silver nitrate; sodium hydroxide / ethanol; water / 1.25 h / 85 °C / Inert atmosphere
2: sodium amalgam; sodium hydroxide / 20 °C / Inert atmosphere

References:

Parker, Matthew A.;Satkiewicz, Emily;Hermann, Thomas;Bergdahl, B. Mikael [Molecules,2011,vol. 16,# 1,p. 281 - 290]