5-chloroisoquinoline-1-carboxylic acid synthesis
- Product Name:5-chloroisoquinoline-1-carboxylic acid
- CAS Number:1179149-33-7
- Molecular formula:C10H6ClNO2
- Molecular Weight:207.61
1231761-25-3
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1179149-33-7
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Yield:1179149-33-7 0.43 g
Reaction Conditions:
Stage #1: 5-chloroisoquinoline-1-carbonitrilewith sodium hydroxide at 80;Inert atmosphere;
Stage #2: with hydrogenchloride in water at 20;Inert atmosphere;
References:
St. Laurent, Denis R.;Serrano-Wu, Michael H.;Belema, Makonen;Ding, Min;Fang, Hua;Gao, Min;Goodrich, Jason T.;Krause, Rudolph G.;Lemm, Julie A.;Liu, Mengping;Lopez, Omar D.;Nguyen, Van N.;Nower, Peter T.;O'Boyle, Donald R.;Pearce, Bradley C.;Romine, Jeffrey L.;Valera, Lourdes;Sun, Jin-Hua;Wang, Ying-Kai;Yang, Fukang;Yang, Xuejie;Meanwell, Nicholas A.;Snyder, Lawrence B. [Journal of Medicinal Chemistry,2014,vol. 57,# 5,p. 1976 - 1994]
70810-23-0
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$45.00/100mg
1179149-33-7
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