5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid synthesis

4synthesis methods

Product Name:5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid
CAS Number:1352396-54-3
Molecular formula:C8H5ClN2O2
Molecular Weight:196.59

Ethyl 5-chloropyrazolo[1,5-a]pyridine-3-carboxylate

886364-13-2
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5-Chloropyrazolo[1,5-a]pyridine-3-carboxylic acid

1352396-54-3
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Yield:1352396-54-3 47%

Reaction Conditions:

with lithium hydroxide monohydrate;sodium hydroxide in methanol at 60; for 1 h;

Steps:

169 Synthesis of 169.2.

To a stirred mixture of 169.1 (400 mg, 1.78 mmol, 1 eq) in methyl alcohol (4 mL) and water (1 mL) were added sodium hydroxide (142 mg, 3.56 mmol, 2 eq). The resulting mixture was stirred for 1 h at 60 °C. The mixture was allowed to cool down to room temperature and diluted with water. The pH value of the solution was adjusted to 3 with IN aqueous hydrochloric acid. The solids were collected by filtration to obtain the crude product 5- chloropyrazolo[l,5-a]pyridine-3-carboxylic acid (169.2, 300 mg, 85%) as a white solid. MS (ES): m/z 197 [M+H]+.

References:

WO2022/87634,2022,A1 Location in patent:Paragraph 00873; 00874

Ethyl 5-AMinoopyrazolo[1,5-a]pyridine-3-carboxylate

1101120-35-7
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1352396-54-3
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References

ethyl 5-((tert-butoxycarbonyl)aMino)pyrazolo[1,5-a]pyridine-3-carboxylate

1101120-33-5
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1352396-54-3
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References

98400-69-2 Synthesis

98400-69-2
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1352396-54-3
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References