![](/CAS/20180702/GIF/99898-84-7.gif)
5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one synthesis
- Product Name:5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one
- CAS Number:99898-84-7
- Molecular formula:C6H4ClN3O
- Molecular Weight:169.57
![5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE](/CAS/GIF/57489-77-7.gif)
57489-77-7
203 suppliers
$13.00/100mg
![5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one](/CAS/20180702/GIF/99898-84-7.gif)
99898-84-7
26 suppliers
$85.00/100mg
Yield:99898-84-7 100%
Reaction Conditions:
with sodium hydroxide in water at 90; for 0.5 h;
Steps:
Preparation of key intermediates a1-a4:
The raw material 5,7-dichloropyrazolo[1,5-a]pyrimidine a1-1 (53.2 mmol, 10 g) was dissolved in 30 mL of 1N NaOH aqueous solution, and the temperature was raised to 90° C. for 0.5 hours to stop the reaction.Cool to room temperature, slowly add 1N hydrochloric acid solution to adjust pH to 7, extract with dichloromethane, and dry over anhydrous Na2SO4to obtain intermediate a1-2 (9 g, quantitative yield)
References:
WO2022/12484,2022,A1 Location in patent:Page/Page column 30