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5-Cyano-6-azaindole-2-carboxylic acid synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0) / DMF (N,N-dimethyl-formamide) / 4.5 h / Heating / reflux
2: sodium hydroxide; water / ethanol / 24 h / 50 °C

References:

OSI PHARMACEUTICALS, INC. WO2004/104001, 2004, A2