5-cyanobenzo[b]thiophene-2-carboxylic acid synthesis

5synthesis methods

Product Name:5-cyanobenzo[b]thiophene-2-carboxylic acid
CAS Number:154650-76-7
Molecular formula:C10H5NO2S
Molecular Weight:203.22

5-CYANO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

146137-93-1
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5-cyanobenzo[b]thiophene-2-carboxylic acid

154650-76-7
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Yield: 98.7%

Reaction Conditions:

with sodium hydroxide in 1,4-dioxane;water

Steps:

114 5-Cyano-benzthiophene-2-carboxylic acid
EXAMPLE 114 5-Cyano-benzthiophene-2-carboxylic acid 5-Cyano-benzthiophene-2-carboxylic acid from Example 113 (6.8 g, 0.0314 mol) was dissolved in dioxane (250 mL), and water (500 ml). Sodium hydroxide (10 N in water, 6.6 mL) was added slowly to the above solution at room temperature for 3 hours. The reaction mixture was then neutralized with concentrated HCl and the product was extracted with ethyl acetate (3*500 mL), dried over sodium sulfate and evaporated to give the 5-cyano-benzthiophene-2-carboxylic acid (6.28 g, 98.7% yield) as a white solid. ¹H NMR (CDCl₃): δ13.85 (br s, 1H), 8.58 (s, 1H), 8.33 (d, 1H, J=8.5 Hz), 8.22 (s, 1H), 7.90 (d, 1H, J=8.5 Hz).

References:

Array Biopharma Inc. US6221914, 2001, B1

ethyl 5-cyanobenzo[b]thiophene-2-carboxylate

105191-14-8
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154650-76-7
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References

5-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER

25785-09-5
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154650-76-7
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References

146137-79-3
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$9.00/250mg

154650-76-7
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References

ETHYL 5-AMINO-1-BENZOTHIOPHENE-2-CARBOXYLATE

25785-10-8
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$65.00/100mg

154650-76-7
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References