5-Cyanouracil synthesis
- Product Name:5-Cyanouracil
- CAS Number:4425-56-3
- Molecular formula:C5H3N3O2
- Molecular Weight:137.1
16462-28-5
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4425-56-3
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Yield:-
Reaction Conditions:
with hydrogenchloride in water at 80 - 100; under 760.051 Torr;Microwave irradiation;
Steps:
3 Step 3
After the reaction in step (2), the intermediate II obtained is added with 2.5-3.0mol / L of dilute hydrochloric acid 30-150mL, and then the microwave reaction temperature is 80-100 ° CThe power is 500W, radiate for 30 to 50 minutes under normal pressure, cool, and filter to get:The urea 1-300 mmol and malononitrile 1-300 mmol are carried out in an amount of equal substances and an excess of 10-80 mL of triethyl orthoformate,The microwave temperature does not exceed 80 degrees at 500W power, otherwise it will affect product purity and color.In order to get good products,The intermediate II in the second step is decolorized with 0.1-0.5 g of activated carbon and acidified with 5-30 mL of glacial acetic acid.
References:
CN104356073,2016,B Location in patent:Paragraph 0024-0027
1187-34-4
28 suppliers
inquiry
4425-56-3
108 suppliers
$9.00/100mg
1187-34-4
28 suppliers
inquiry
4425-56-3
108 suppliers
$9.00/100mg