5-(dibenzylamino)-2-methylpentan-2-ol synthesis
3synthesis methods
- Product Name:5-(dibenzylamino)-2-methylpentan-2-ol
- CAS Number:1455037-19-0
- Molecular formula:C20H27NO
- Molecular Weight:297.43
Yield:1455037-19-0 77%
Reaction Conditions:
in tetrahydrofuran at 0 - 70;Inert atmosphere;
Steps:
111 Synthesis of 5-(dibenzylamino)-2-methylpentan-2-ol
Treat a 0°C solution of methyl 4-(dibenzylamino)butanoate (19.5 g, 65.6 mmol) in THF (100 mL), under N2, drop-wise with methyl magnesium bromide (65.6 mL, 196.9 mmol) over 1 h, then heat at 70°C overnight. Cool to 0°C, add satd. NH4C1 drop-wise, extract with EtOAc (3x), wash the combined organics with brine, dry over Na2S04, concentrate and purify via silica gel chromatography to afford the title compound (15 g, 77%).
References:
WO2013/134298,2013,A1 Location in patent:Page/Page column 70-71