ChemicalBook CAS DataBase List 5-(difluoromethoxy)-2-fluoropyridine

5-(difluoromethoxy)-2-fluoropyridine synthesis

3synthesis methods

Product Name:5-(difluoromethoxy)-2-fluoropyridine
CAS Number:130318-80-8
Molecular formula:C6H4F3NO
Molecular Weight:163.1

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Yield:-

Steps:

Multi-step reaction with 3 steps
1: 92 percent / K₂CO₃ / dimethylformamide / 6.5 h / 80 - 90 °C
2: 57 percent / H₂ / 10percent Pd/C / acetic acid / 8 h / 25 - 28 °C / 42753.4 Torr
3: 63 percent / NaNO₂, HF / CH₂Cl₂; methanol / 1) -78 deg C, 2) rt

References:

Fuss, Andreas;Koch, Volker [Synthesis,1990,# 8,p. 681 - 685]

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References

Pyridine, 5-(difluoromethoxy)-2-[2-(4-nitrophenyl)diazenyl]-

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References